Stereotactic radiosurgery for residual and recurrent central neurocytoma

mohameth faye



Background:  Central neurocytoma (CN) is a rare benign tumor of central nervous system that is typically located in the lateral ventricle and constitute 0.1–0.5% of all primary brain tumors.

Methods: We are relating retrospectively the results of 11 patients who underwent Gamma knife radiosurgery  for CNs in the Gamma unit at functional and stereotactic neurosurgery service in Marseille from January 1999 to December 2015.The mean age at Gamma knife radiosurgery (GKS) was 25.12 years (range17-41 years). All patients underwent surgery before (GKS) with a mean delay of 19, 37 months (6-62months). The prescribed mean dose delivered to the tumor margin was 19, 1 Gy(12-24Gy).The mean volume of treatment was 4.4mL (1.03-10.7mL).The mean time follow-up was 55.2 months (7.2-108 months).

 Results: The local tumor control was 90% at the final follow-up time. One recurring tumor was local (4.67years after GKS) and 2 were “out-of-field” recurrence (5.42 and 6.8 years after GKS) .Repeat stereotactic radiosurgery was performed in two patients with an average delay between the two of 5.91years and an average dose of 14.34Gy. The local tumor control was also unrelated to the prescribed dose (p= 0.89) and the tumor volume (p= 0.67). No deaths and no radiation injury were observed during our follow-up.

Conclusion: Gamma knife radiosurgery is now the treatment of choice for sub-totally resected and local central neurocytoma recurrence with higher tumor control rates and low complications while the small number of patients studied in the literature.


Key words: Central neurocytoma – Gamma knife surgery- stereotactic radiosurgery


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