Investigation of antioxidant activity of some bis-benzimidazole in Tetrahymena thermophila stressed cells
Amine OUAKET, Boutaina ADDOUM, Bouchra EL KHALFI, Abdelaziz SOUKRI, Noureddine KNOUZI, Mohamed BERRADA
Abstract
In this paper, we present experimental findings on the protective effect of some bis-benzimidazole molecules against oxidative (H2O2) and nitrosative (SNP) stress using the protozoan T. thermophila as a cellular model. The results of this article show that the molecules 2,2’-Benzendiyl-1,4-Bis-(5-amino-1H-benzimidazole) and 2,2’-Octandiyl-1,8-Bis-(quinolin-8-ol-5-azo-1H-benzimidazole) have a protective effect against stress important than the molecule 2,2’-Benzendiyl-1,4-Bis-(1H-benzimidazole).