A library of 900 pyrimidine derivatives was screened virtually on vascular endothelial growth factor (VEGF) using Vlife MDS 4.1 software to identify potential candidates with anticancer and anticataract activity. A series of 2,4,6-substituted pyrimidine derivatives were synthesized in good yields from chalcones, where chalcones have been prepared according to claisen - schimidt condensation by condensing various ketones with aromatic aldehyde in presence of ethanol and sodium or potassium hydroxide. Their structures were confirmed by  IR, ¹H NMR and mass spectra. Biological screening of the potential candidates was done for anticancer and anticataract activity. The present study reveals that a derivative of pyrimidine shows activity against breast cancer and diabetic retinopathy through inhibition of VEGF.