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Acetylcholinesterase, Tyrosinase, α-Glucosidase inhibition by Ammodaucus leucotrichus Coss. & Dur. Fruits Essential oil and Ethanolic Extract and Molecular Docking Analysis


 
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1. Title Title of document Acetylcholinesterase, Tyrosinase, α-Glucosidase inhibition by Ammodaucus leucotrichus Coss. & Dur. Fruits Essential oil and Ethanolic Extract and Molecular Docking Analysis
 
2. Creator Author's name, affiliation, country A. Boumezzourh; Laboratory of Nanotechnology, Materials and Environment, Department of Chemistry, Faculty of Science, University Mohammed V, Av. Ibn Batouta, BP. 1014 Rabat, Morocco; Morocco
 
2. Creator Author's name, affiliation, country M. Ouknin; Laboratory of Nanotechnology, Materials and Environment, Department of Chemistry, Faculty of Science, University Mohammed V, Av. Ibn Batouta, BP. 1014 Rabat, Morocco
 
2. Creator Author's name, affiliation, country M. Merzouki; Laboratory of Applied Chemistry and Environment (LCAE) Team (ECOMP), Mohamed 1st- Oujda, Morocco.; Morocco
 
2. Creator Author's name, affiliation, country A. Dabbous-Wach; Laboratory of Chemistry of Natural Products, UMR CNRS 6134, Faculty of Sciences and Techniques, University of Corsica, France.; France
 
2. Creator Author's name, affiliation, country B. Hammouti; Euro-Mediterranean University of Fes, Fes 30070, BP 15, Morocco Laboratory of Industrial Engineering, Energy and The Environment (LI3E) SUPMTI Rabat, Morocco; Morocco
 
2. Creator Author's name, affiliation, country P. S. Umoren; Department of Bioengineering, Cyprus International University, Nicosia, 98258 via Mersin 10, Turkey; Turkey
 
2. Creator Author's name, affiliation, country J. Costa; Laboratory of Chemistry of Natural Products, UMR CNRS 6134, Faculty of Sciences and Techniques, University of Corsica, France.; France
 
2. Creator Author's name, affiliation, country A. Challioui; Laboratory of Applied Chemistry and Environment (LCAE) Team (ECOMP), Mohamed 1st- Oujda, Morocco.
 
2. Creator Author's name, affiliation, country Saviour A Umoren; King Fahd University of Petroleum & Minerals; Saudi Arabia
 
2. Creator Author's name, affiliation, country L. Majidi; Laboratory of Nanotechnology, Materials and Environment, Department of Chemistry, Faculty of Science, University Mohammed V, Av. Ibn Batouta, BP. 1014 Rabat, Morocco
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Ammodaucus leucotrichus; minerals composition; essential oil; AChE; Tyrosinase; α-Glucosidase; Molecular docking
 
4. Description Abstract

Medicinal and aromatic plants serve as valuable reservoirs of bioactive molecules and mineral compounds that are harnessed for therapeutic and agro-food applications. The objective of this study was to assess the inhibitory enzyme properties of Ammodaucus leucotrichus Coss & Dur fruit essential oil, as well as its aqueous and ethanol extracts, against acetylcholinesterase, tyrosinase, and α-glucosidase. Additionally, the antioxidant activity of these natural mixtures was evaluated using three different methods: DPPH, FRAP, and β-carotene bleaching tests. Furthermore, this research endeavors to examine the mineral constituents of various components of the plant under investigation. The various natural combinations that were examined exhibited a notable inhibitory impact on the enzymes acetylcholinesterase (67.56-92.30%), tyrosinase (57.52-63.44%), and α-glucosidase (61.22-72.49%). The analyzed extracts also demonstrate a significant antioxidant activity. Furthermore, the results obtained from the analysis indicate a notable presence of both macro and microelements, such as calcium (2.028 mg/g for leaves and 1.787 mg/g for fruits), within the Ammodaucus leucotrichus Coss & Dur plant. The current study supports the significance of utilizing Ammodaucus leucotrichus Coss & Dur fruits in the medicinal and agro-alimentary sectors. The utilization of molecular docking techniques was employed in order to make predictions regarding the therapeutic effects of Ammodaucus leucotrichus Coss & Dur fruits.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 26-10-2023
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/morjchem/article/view/43316
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48317/IMIST.PRSM/morjchem-v11i04.43316
 
11. Source Title; vol., no. (year) Moroccan Journal of Chemistry; Vol 11, No 04 (2023): pp. 897-1318
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2023 Moroccan Journal of Chemistry