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Investigating the Biological Activities of Moroccan Cannabis Sativa L Seed Extracts: Antimicrobial, Anti-inflammatory, and Antioxidant Effects with Molecular Docking Analysis


 
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1. Title Title of document Investigating the Biological Activities of Moroccan Cannabis Sativa L Seed Extracts: Antimicrobial, Anti-inflammatory, and Antioxidant Effects with Molecular Docking Analysis
 
2. Creator Author's name, affiliation, country S. Haddou; Morocco
 
2. Creator Author's name, affiliation, country K. Mounime; Laboratory of Applied Chemistry & Environment, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco.; Morocco
 
2. Creator Author's name, affiliation, country E. Loukili; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco; Morocco
 
2. Creator Author's name, affiliation, country D. Ou-Yahia; Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty, Sidi Mohnmed Ben Abdellah University, P.O. Box 2202, Fez, Morocco.; Morocco
 
2. Creator Author's name, affiliation, country A. Hbika; Laboratory of Applied Chemistry & Environment, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco.; Morocco
 
2. Creator Author's name, affiliation, country M. Yahyaoui Idrissi; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco.; Morocco
 
2. Creator Author's name, affiliation, country A. Legssyer; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco.; Morocco
 
2. Creator Author's name, affiliation, country H. Lgaz; Innovative Durable Building and Infrastructure Research Center, Center for Creative Convergence Ed-ucation, Hanyang University ERICA, 55 Hanyangdaehak-ro, Sangrok-gu, Ansan-si, Gyeonggi-do 15588, South Korea; Korea, Republic of
 
2. Creator Author's name, affiliation, country A. Asehraou; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco
 
2. Creator Author's name, affiliation, country R. Touzani; Laboratory of Applied Chemistry & Environment, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda, Morocco; Morocco
 
2. Creator Author's name, affiliation, country B. Hammouti; Euro-Mediterranean University of Fes, Fes 30070, BP 15, Morocco; Morocco
 
2. Creator Author's name, affiliation, country A. Chahine; Laboratory of Advanced Materials and Process Engineering, Faculty of Science, University Ibn Tofail, University Street, B.P 242, Kenitra, Morocco,; Morocco
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Cannabis sativa L.; Natural extracts; Antioxidant power; Antimicrobial power; Anti-inflammatory activity
 
4. Description Abstract The present study focuses on assessing the bioactive potential of Cannabis sativa L. seed extracts, specifically the organic and aqueous extracts derived from Ketama hemp seeds harvested in Morocco. We tested the antioxidant capacities of the extracts, specifically their ability to scavenge DPPH free radicals. The ethanolic Cannabis sativa L. seed extract was particularly effective, demonstrating the lowest IC50 value of 0.36mg/mL±0.01, outperforming the reference compound ascorbic acid, which had an IC50 value of 0.68mg/mL±0.02. This suggests a significantly high antioxidant potential of the ethanolic extract against the DPPH radical. The β-carotene bleaching test further supported these findings, with the ethanolic and hexanolic extracts showing substantial antioxidant activity, inhibiting the coupled oxidation of linoleic acid and β-carotene by 36%±0.12 and 33%±0.14, respectively. We also assessed the antimicrobial potency of the seed extracts using the Muller-Hinton Agar well diffusion method. The ethanolic extract demonstrated the highest inhibition zone diameter (IZ = 23 mm) against Penicillium sp., whereas the hexane extract had the smallest IZ (07 mm) against Listeria monocytogenes. Microdilution method in a 96-well microplate was employed to determine the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) of the extracts. All extracts showed inhibitory effects against all tested bacterial and fungal strains, with MIC, MBC, and MFC values ranging from 0.03 to 1.25 mg/mL. Lastly, the anti-inflammatory activity of the extracts was tested using the RBC method. The findings indicated that all extracts significantly inhibited heat/hypotonia-induced erythrocyte haemolysis, further exploring their potential therapeutic value.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 09-08-2023
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/morjchem/article/view/42100
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48317/IMIST.PRSM/morjchem-v11i04.42100
 
11. Source Title; vol., no. (year) Moroccan Journal of Chemistry; Vol 11, No 04 (2023): pp. 897-1318
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2023 Moroccan Journal of Chemistry