Reverse Docking on Five Original PPO Structures: Plant, Bacterial, and Human
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Reverse Docking on Five Original PPO Structures: Plant, Bacterial, and Human |
| 2. | Creator | Author's name, affiliation, country | O. Abdessadak, H. Hajji, S. Mehanned, M. Aziz Ajana, T. Lakhlifi, M. Bouachrine; Morocco |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | PPO, N-phenylphthalimide, Reverse Docking, MD simulations. |
| 4. | Description | Abstract | Protoporphyrinogen oxidase has known remarkable interest in biochemical studies, it is considered a perfect target for the development of new herbicides. PPO herbicides have been developed for more than forty years, and research on this enzyme remains until today, to find new more effective herbicides. In this work, we investigated the inhibitory activity of a compound derived from N-phenylphthalimide with the highest inhibitory activity among a series of 29 molecules, on five PPO structures from various origins, including Plant origin, bacterial, and human, we have based on Reverse Docking, to know the affinity between the inhibitor and the five targets, and the different ligand-receptor interactions. As well as Molecular Dynamics. Interesting results have been obtained, which may help us to discover new targets concerning herbicides. |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 16-06-2022 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://revues.imist.ma/index.php/morjchem/article/view/33065 |
| 10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.48317/IMIST.PRSM/morjchem-v10i3.33065 |
| 11. | Source | Title; vol., no. (year) | Moroccan Journal of Chemistry; Vol 10, No 3 (2022) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2022 Moroccan Journal of Chemistry |