Synthesis of 3,3-di(1-(2-phenylbenzyl)indole-3-yl)-5-bromoindoline-2-one
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Synthesis of 3,3-di(1-(2-phenylbenzyl)indole-3-yl)-5-bromoindoline-2-one |
| 2. | Creator | Author's name, affiliation, country | Dyah Ayu Titisari, Eko Santoso, Mardi Santoso; Abstract 3,3-Di(indol-3-yl)indoline-2-one (1a) was firstly isolated from the culture of a bacterium of Vibrio sp., which was separated from marine sponge Hyrtios altum. This natural microbial product exhibited various bioactivities for examples antimicrobial, antifungal, anticonvulsant, anticancer, antidiabetic. Herewith we report synthesis of 3,3-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3) as a new analogue of 3,3-di(indol-3-yl)indoline-2-one (1a). N-Alkylation of indole gave 1-(2-phenylbenzyl)indole (4), which on treatment with 5-bromoisatin under acidic condition afforded 3,3'-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3). Structure of compound (3) was established by NMR and high-resolution mass spectroscopies.; Morocco |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Synthesis, 3,3-di(indol-3-yl)indoline-2-one, analogue |
| 4. | Description | Abstract | 3,3-Di(indol-3-yl)indoline-2-one (1a) was firstly isolated from the culture of a bacterium of Vibrio sp., which was separated from marine sponge Hyrtios altum. This natural microbial product exhibited various bioactivities for examples antimicrobial, antifungal, anticonvulsant, anticancer, antidiabetic. Herewith we report synthesis of 3,3-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3) as a new analogue of 3,3-di(indol-3-yl)indoline-2-one (1a). N-Alkylation of indole gave 1-(2-phenylbenzyl)indole (4), which on treatment with 5-bromoisatin under acidic condition afforded 3,3'-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3). Structure of compound (3) was established by NMR and high-resolution mass spectroscopies. |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 26-05-2022 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://revues.imist.ma/index.php/morjchem/article/view/32646 |
| 10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.48317/IMIST.PRSM/morjchem-v10i2.32646 |
| 11. | Source | Title; vol., no. (year) | Moroccan Journal of Chemistry; Vol 10, No 2 (2022) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2022 Moroccan Journal of Chemistry |