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PKP Metadata Items |
Metadata for this Document |
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| 1. |
Title |
Title of document |
Chemical Transformation of Pyrazine Derivatives |
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| 2. |
Creator |
Author's name, affiliation, country |
Widiastuti Agustina Eko Setyowati, Yana Maolana Syah, Ihsanawatia, Anita Alni; Morocco |
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Subject |
Discipline(s) |
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Subject |
Keyword(s) |
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| 4. |
Description |
Abstract |
Pyrazine is a group of N-containing heterocycle compounds found in both nature and synthetic drugs. In fact, the existence of the pyrazine ring as a basic framework in many drug compounds indicates that these compounds are important in drug development/design. Pyrazine as medicinal compounds, especially as anticancer, contain amine or amide groups, while some functional groups, like bromo, methyl, methoxy, nitro, amino, and methylamino have antimigration and antiproliferative activities. Based on these considerations, various chemical transformations, consisting of nitration, acetylation, esterification, bromination, and amidation have been carried out on commercially available pyrazine based starting materials containing amine or amide groups. Those chemical transformation resulting in seven pyrazine derivatives that have the potential to be applied as anticancer, namely 3-hydroxy-6-nitropyrazine-2-carboxamide (1), 3-(acetylcarbamoyl)-5-bromopyrazine-2-yl acetate (2), methyl 3-aminopyrazine-2-carboxylate (3), 3-amino-N-phenylpyrazine-2-carboxamide (4), 3-amino-N-methylpyrazine-2-carboxamide (5), methyl 3-amino-6-bromopyrazine-2-carboxylate (6), and 3,5-dibromopyrazine-2-amine (7). The molecular structures of these compounds were elucidated based on the 1H NMR, 13C NMR and Mass Spectral data. |
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| 5. |
Publisher |
Organizing agency, location |
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| 6. |
Contributor |
Sponsor(s) |
Pyrazine; Drugs Development; Chemical Transformation; Molecular Structure |
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| 7. |
Date |
(YYYY-MM-DD) |
26-05-2022
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Type |
Status & genre |
Peer-reviewed Article |
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Type |
Type |
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| 9. |
Format |
File format |
PDF |
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| 10. |
Identifier |
Uniform Resource Identifier |
https://revues.imist.ma/index.php/morjchem/article/view/32643 |
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| 10. |
Identifier |
Digital Object Identifier (DOI) |
https://doi.org/10.48317/IMIST.PRSM/morjchem-v10i2.32643 |
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| 11. |
Source |
Title; vol., no. (year) |
Moroccan Journal of Chemistry; Vol 10, No 2 (2022) |
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| 12. |
Language |
English=en |
en |
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| 13. |
Relation |
Supp. Files |
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| 14. |
Coverage |
Geo-spatial location, chronological period, research sample (gender, age, etc.) |
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| 15. |
Rights |
Copyright and permissions |
Copyright (c) 2022 Moroccan Journal of Chemistry
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