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Synthesis and antimicrobial activity of some quinoxaline derivatives


 
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1. Title Title of document Synthesis and antimicrobial activity of some quinoxaline derivatives
 
2. Creator Author's name, affiliation, country A. El Janati
 
2. Creator Author's name, affiliation, country Y. Ouzidan; Morocco
 
2. Creator Author's name, affiliation, country Y. Kandri Rodi
 
2. Creator Author's name, affiliation, country F. Ouazzani Chahdi
 
2. Creator Author's name, affiliation, country M. Chraibi
 
2. Creator Author's name, affiliation, country K. Fikri Benbrahim
 
2. Creator Author's name, affiliation, country I. Cherif Alaoui
 
2. Creator Author's name, affiliation, country A. El Hakmaoui
 
2. Creator Author's name, affiliation, country M. Safi
 
2. Creator Author's name, affiliation, country M. Akssira
 
2. Creator Author's name, affiliation, country El M. Essassi
 
3. Subject Discipline(s)
 
3. Subject Keyword(s)
 
4. Description Abstract

Some new structural motifs containing the quinoxaline nucleus have been synthesized and examined for their pharmacological properties. In this study, 6-chloroquinoxaline-2,3(1H, 4H)-dione and 6 nitroquinoxaline-2,3(1H, 4H)-dione were synthesized as basic nuclei for the preparation of the new quinoxaline-2,3-diones by alkylation reactions under the conditions of phase transfer catalysis. The products were characterized by spectroscopic methods 1H and 13C NMR. Then, the synthesized products were tested for their antibacterial effects against two bacterial strains. The values of minimum inhibitory concentrations (MIC) vary according to the nature of the alkyl bonded to the quinoxaline nucleus.

 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 06-08-2021
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/morjchem/article/view/25855
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48317/IMIST.PRSM/morjchem-v9i2.25855
 
11. Source Title; vol., no. (year) Moroccan Journal of Chemistry; Vol 9, No 2 (2021)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2021 Moroccan Journal of Chemistry