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This study was carried out with an objective to synthesis and investigate the antibacterial potentials of resorcinic acid. The aim of the study is to synthesis and assess the antimicrobial activity and to determine the zone of inhibition of resorcinic acid on Staphylococcus aureus bacterial. Today many infectious diseases are common. All of the diseases are caused by agents such as viruses or bacteria which are pathogenic and Staphylococcus aureus is one of the pathogenic bacteria. In addition, many antibiotics are not able to work properly because of the resistance of bacteria against the exciting antibiotics. Therefore, research to discover the new anti-bacterial compounds is important to do. The synthesis of resorcinic acid was conducted by reacting resorcinol and carbon dioxide.  The characterization of the target compounds was performed by IR and MS spectrometers. The growth of the tested bacteria was observed using a colony counter to see the diameter of the resistance which was caused by the test solution. The antibacterial activity test indicated that resorcinic acid had the potential as an antibacterial against Staphylococcus aureus. The activity was known from its inhibition zone. At the concentration of 100 ppm, resorcinic acid solution showed an inhibitory diameter of 17.4 mm and amoxicillin antibiotic showed of 16.6 mm. It is mean the resorsinic acid can be used as the potential antibiotic agent.