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Theoretical Analysis of the Regioselective Electrophilic Chloration and Chemioselective Esterification of the pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid


 
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1. Title Title of document Theoretical Analysis of the Regioselective Electrophilic Chloration and Chemioselective Esterification of the pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid
 
2. Creator Author's name, affiliation, country A. Barhoumi, Y. Hakmaoui, M. El Ghozlani O. Amiri, A. El Haib, M. Zoubir, S. Jorio, M. El Idrissi; Morocco
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) DFT calculation; Sulfonyl chlorides; regioselectivity; chemoselectivity; pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid.
 
4. Description Abstract The reaction between the pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid 1 and SOCl2 has been studied within the Density Functional Theory (DFT) B3LYP/6-31G(d,p) computational level. Examination of the conceptual DFT reactivity indices permit the elucidation of the reactivity, and the regio- and chemoselectivity experimentally observed. The possible regioselective channels and chemoselective channels were explored and characterized. Analysis of the energies associated with the different reaction pathways shows that this reaction is completely chemioselective and regioselective, in conformity with the experimental results.
 
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6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 01-02-2020
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/morjchem/article/view/17120
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48317/IMIST.PRSM/morjchem-v8i1.17120
 
11. Source Title; vol., no. (year) Moroccan Journal of Chemistry; Vol 8, No 1 (2020)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2019 Moroccan Journal of Chemistry