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In vitro assessments of cytotoxic and cytostatic effect of two [Cu(dien)(N-N)]Br2 complexes on L6, HCT, PC3 and HepG2 cancer cells


 
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1. Title Title of document In vitro assessments of cytotoxic and cytostatic effect of two [Cu(dien)(N-N)]Br2 complexes on L6, HCT, PC3 and HepG2 cancer cells
 
2. Creator Author's name, affiliation, country A. Sawafta, B. Mansour, S. Amereih, A. Zarrouk, A. Chetouani, I. Warad.
 
3. Subject Discipline(s)
 
3. Subject Keyword(s)
 
4. Description Abstract

Two new Cu(II) complexes of type [Cu(dien)(N-N)] Br2 (dien is diethlylenetriamine, C1 complex with N-N = diethlylenetriamine and C2 complex with N-N = propyl-1,3-diamine) were made valuable  and in vitro screened for both cytostatic and cytotoxic activities against four cell lines: colon cancer (HCT), liver cancer (HepG2), prostate cancer (PC3) and as control cell (L6) human muscle cell was used via MTT test. The results reflected these complexes as a promising activity antiprolifrative agent against the used cell lines indicating that C1 and C2 complexes have a high anticancer activity at non-toxic concentrations.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s) Copper(II), Diamine, MTT, Anticancer
 
7. Date (YYYY-MM-DD) 29-12-2019
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/morjchem/article/view/16676
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48317/IMIST.PRSM/morjchem-v7i4.16676
 
11. Source Title; vol., no. (year) Moroccan Journal of Chemistry; Vol 7, No 4 (2019)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2019 Moroccan Journal of Chemistry