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PKP Metadata Items |
Metadata for this Document |
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| 1. |
Title |
Title of document |
Targeting VEGF to design pyrimidines against breast cancer and diabetic retinopathy |
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| 2. |
Creator |
Author's name, affiliation, country |
Ramesh L. Sawant; Dr. Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar; India |
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| 2. |
Creator |
Author's name, affiliation, country |
Rahul Kale |
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| 2. |
Creator |
Author's name, affiliation, country |
Jyoti Wadekar |
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| 2. |
Creator |
Author's name, affiliation, country |
Amol Ghodechor |
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| 2. |
Creator |
Author's name, affiliation, country |
Abhijit Sherkar |
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| 3. |
Subject |
Discipline(s) |
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| 3. |
Subject |
Keyword(s) |
Pyrimidines; VEGF inhibitor; Molecular docking; Anticancer, anticataract activity. |
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| 4. |
Description |
Abstract |
A library of 900 pyrimidine derivatives was screened virtually on vascular endothelial growth factor (VEGF) using Vlife MDS 4.1 software to identify potential candidates with anticancer and anticataract activity. A series of 2,4,6-substituted pyrimidine derivatives were synthesized in good yields from chalcones, where chalcones have been prepared according to claisen - schimidt condensation by condensing various ketones with aromatic aldehyde in presence of ethanol and sodium or potassium hydroxide. Their structures were confirmed by IR, 1H NMR and mass spectra. Biological screening of the potential candidates was done for anticancer and anticataract activity. The present study reveals that a derivative of pyrimidine shows activity against breast cancer and diabetic retinopathy through inhibition of VEGF. |
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| 5. |
Publisher |
Organizing agency, location |
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| 6. |
Contributor |
Sponsor(s) |
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| 7. |
Date |
(YYYY-MM-DD) |
30-07-2018
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| 8. |
Type |
Status & genre |
Peer-reviewed Article |
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| 8. |
Type |
Type |
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| 9. |
Format |
File format |
PDF |
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| 10. |
Identifier |
Uniform Resource Identifier |
https://revues.imist.ma/index.php/morjchem/article/view/10273 |
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| 10. |
Identifier |
Digital Object Identifier (DOI) |
https://doi.org/10.48317/IMIST.PRSM/morjchem-v6i4.10273 |
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| 11. |
Source |
Title; vol., no. (year) |
Moroccan Journal of Chemistry; Vol 6, No 4 (2018) |
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| 12. |
Language |
English=en |
en |
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| 13. |
Relation |
Supp. Files |
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| 14. |
Coverage |
Geo-spatial location, chronological period, research sample (gender, age, etc.) |
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| 15. |
Rights |
Copyright and permissions |
Copyright (c) 2018 Moroccan Journal of Chemistry
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