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Synthesis of some novel 6,6'-(1,4-phenylene)bis(4-phenylpyrimidin-2-ol/-2-amine/2-thiol catalyzed by MgFe2O4 and evaluation of their antimicrobial activities


 
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1. Title Title of document Synthesis of some novel 6,6'-(1,4-phenylene)bis(4-phenylpyrimidin-2-ol/-2-amine/2-thiol catalyzed by MgFe2O4 and evaluation of their antimicrobial activities
 
2. Creator Author's name, affiliation, country S. Bansala P. P. Singha; GLA University, Mathura 281406 INDIA; India
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Antimicrobial activity, MgFe2O4 Magnetic nanoparticle, Heterogeneous catalyst, Bisheterocycles, Reusable catalyst
 
4. Description Abstract

Novel bisheterocycles 4-6 have been synthesized by green approach using cheaper, reusable, non toxic magnetically separable MgFe2O4 as nano catalyst. Bis chalcone and binucleophiles were treated on MgFe2O4 heterogenous catalyst in refluxing ethanol to afford the novel bis heterocycles 4-6 in very good yields with very less reaction time. The newly synthesized compounds were characterized by NMR (1H & 13C), FTIR and mass spectroscopy, thereafter evaluated for their antibacterial activities against Bacillus subtilis (MTCC No.121), Escherichia coli (MTCC No.118), Staphylococcus aureus (MTCC No. 96) and Salmonella typhi (MTCC No. 98) while antifungal activities were tested against Aspergillus niger (MTCC No. 281) and Candida albicans  (MTCC No. 2479) using disc diffusion method. The reported novel compounds exhibited a good range of antimicrobial activities, opening plethora of oppournities in the field of research in antibiotics.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s) GLA University Mathura, India
 
7. Date (YYYY-MM-DD) 30-07-2018
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/morjchem/article/view/10266
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48317/IMIST.PRSM/morjchem-v6i4.10266
 
11. Source Title; vol., no. (year) Moroccan Journal of Chemistry; Vol 6, No 4 (2018)
 
12. Language English=en en
 
13. Relation Supp. Files Synthesis of some novel 6,6'-(1,4-phenylene)bis(4-phenylpyrimidin-2-ol/-2-amine/2-thiol catalyzed by MgFe2O4 and evaluation of their antimicrobial activities (7MB)
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2018 Moroccan Journal of Chemistry