Anti-inflammatory and Antioxidant Activity Screening for New Steroidal Schiff Bases

Abstract

In the present work, two aldehyde derivatives were synthesized one from cholesterol and one from ergosterol and further condensed with three different primary amines (2-amino 6-fluoro benzathiazole, thiosemicarbazide, carbohydrazide) to yield the corresponding Schiff’s bases. The synthesized compounds were verified using spectral analysis, including IR, 1H-NMR, and GC Mass, and were tested for antioxidant and anti-inflammatory properties. From the synthetic materials, three to four compounds showed significant anti-inflammatory and antioxidant activities.