Anti-Hyperglycaemic properties of an ethanolic extract from Costus spicatus (jacq) on Streptozotocin-induced diabetic male albino Wistar rats

Abstract

In this contribution, for the first time an ethanolic extract of Costus spicatus, was screened for evaluating its composition followed by its in vitro antidiabetic activity. Both spectrometric and gas chromatography techniques were employed along with the antidiabetic activity on (STZ)-Streptozotocin-induced male albino Wistar rats. A rich phytochemical content, made up of tannins, saponins, flavonoids, steroids, etc, was attained together with a high amount of ash content (11.3%) and moisture content (1.27%); further, a total of 25 compounds were positively identified by GC-MS analysis. For antidiabetic activity, different treatment period of 0th day, 21th days, 45th days were taken into consideration. Histopathological studies, considering high blood glucose levels, Serum Glutamic oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), and Alkaline Phosphatase (ALP) levels highlighted no damage in the pancreas tissue cells. Based on the findings of this study, such an insulin plant might be considered a potential source and therapeutic agent for diabetic patients.