Synthesis and antimicrobial activity of some quinoxaline derivatives

Abstract

Some new structural motifs containing the quinoxaline nucleus have been synthesized and examined for their pharmacological properties. In this study, 6-chloroquinoxaline-2,3(1H, 4H)-dione and 6 nitroquinoxaline-2,3(1H, 4H)-dione were synthesized as basic nuclei for the preparation of the new quinoxaline-2,3-diones by alkylation reactions under the conditions of phase transfer catalysis. The products were characterized by spectroscopic methods ¹H and ¹³C NMR. Then, the synthesized products were tested for their antibacterial effects against two bacterial strains. The values of minimum inhibitory concentrations (MIC) vary according to the nature of the alkyl bonded to the quinoxaline nucleus.