Synthesis, Spectral and Biological Studies of some Transition Metal Complexes Derived from Schiff base of Xipamide Drug

Abstract

Transition metal complexes of Mn(II), Fe(II), Ni(II), Co(II) have been synthesized from Schiff base of Xipamide drug, that is, 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2- hydroxybenzamide. Elemental analyses suggest ML₂ stoichiometry for all metals. All the complexes are non-electrolytic in nature as suggested by conductivity data. The ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and phenolic oxygen. Magnetic susceptibility, electronic, IR, ESR spectral studies suggest that the complexes possess octahedral geometry. The ligand and some of the synthesized complexes were screened for their antibacterial and diuretic activity also.