Synthesis and in-vitro Antitumor Evaluation ofNovel3- Phenylquinoxaline Containing 1,2,3-triazole, Isoxazole, Isoxazoline and Pyrazole

Authors

  • Hanane Benzeid Laboratoire de Chimie Organique Hett\rocyclique,URAC 21, Facultt\ des Sciences, Universite Mohammed V-Agdai,Av.lbn Battouta, BP 1014, Rabat, Morocco.
  • Saoussan El Haddar Laboratoire de Biochimie et Immunologie, Facultt\ des Sciences, University Mohammed V Agdal, Rabat, Morocco
  • Stephane Massip Laboratoire de Chimie Physique et Minerale, EA4138 Pharmacochimie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076, BORDEAUX Cedex
  • Rachid Bouhfid Institute of Nanomaterials and Nanotechnology (INANOTECH), MASCIR Foundation, EN SET, Av. de l'Armee Royale, Madinat El Irfane 10100- Rabat, Morocco.
  • Jean-Michel Leger Laboratoire de Chimie Physique et Minerale, EA4138 Pharmacochimie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076, BORDEAUX Cedex
  • Abdelaziz Benjouad Laboratoire de Biochimie et Immunologie, Facultt\ des Sciences, Universite Mohammed V Agdal, Rabat, Morocco.
  • El Mokhtar Essassi Laboratoire de Chimie Organique Hett\rocyclique,URAC 21, Facultt\ des Sciences, Universite Mohammed V-Agdai,Av.lbn Battouta, BP 1014, Rabat, Morocco Institute of Nanomaterials and Nanotechnology (INANOTECH), MASCIR Foundation, EN SET, Av. de l'Armee Royale, Madinat El Irfane 10100- Rabat, Morocco. Academie Hassan II des Sciences et Techniques, Rabat, Morocco

DOI:

https://doi.org/10.34874/IMIST.PRSM/fsejournal-v3i1.28377

Keywords:

3-phenyl-quinoxaline, antitumor activity, nitrile imine, nitrile oxide, azide, 1, 3- dipolar cycloaddition

Abstract

The 1,3-dipolar cyc/oaddition reaction of alkylated quinoxaline derivatives with nitrile
imine, nitrile oxides and azide was investigated. The structures of obtained cycloadducts were characterized by FT-lR, 1H, 13C NMR spectra, mass spectrometry and single-crystal X-ray diffraction analysis. The synthesized products were subjected to in-vitro biological evaluation against two human tumor cells (BxPc-3 and Pane-l). Several tested compounds showed significant activities.

Downloads

Published

01-02-2014

Issue

Vol. 3 No. 1 (2013)

Section

Physics, Chemistry, Engineering Sciences