EXPRESSION PROFILE OF BREAST CANCER IN MOROCCAN WOMEN

Authors

  • Salah Eddine AYOUBI 1-Genomics Lab, Fondazione Edo ed Elvo Tempia, Biella, Italy 2- Genetics and Molecular Pathology Lab, Medical School, University Hassan II, Casablanca, Morocco
  • Paola OSTANO Genomics Lab, Fondazione Edo ed Elvo Tempia, Biella, Italy
  • Maurizia MELLO-GRAND Genomics Lab, Fondazione Edo ed Elvo Tempia, Biella, Italy
  • Ilaria GREGNANIN Genomics Lab, Fondazione Edo ed Elvo Tempia, Biella, Italy
  • Mohamed ELKARROUMI Mohammed VI Center for Cancer Treatment, University Hospital Center Ibn Rochd, Casablanca.
  • Giovanna CHIORINO Genomics Lab, Fondazione Edo ed Elvo Tempia, Biella, Italy
  • Sellama NADIFI Genetics and Molecular Pathology Lab, Medical School, University Hassan II, Casablanca

DOI:

https://doi.org/10.34874/IMIST.PRSM/fsejournal-v8i2.28295

Keywords:

Breast cancer, Morocco, gene expression

Abstract

Breast cancer (BC) is a major public health problem. Several transcriptomic studies have been conducted worldwide to elucidate breast carcinogenesis, but more are needed in developing countries like Morocco. This study was carried out to establish a genetic signature of breast cancer in Moroccan women.


Transcriptome profiling of 20 fresh breast tumors and normal matched adjacent breast tissues from Moroccan BC patients was analyzed using DNA microarrays.

1800 differentially expressed genes (DEGs) were identified: up-regulated genes were involved in mammary gland development, gene expression and signal transduction, while down-regulated genes were directly associated with regulation of kinase activity and signal transduction by protein phosphorylation.

This study is to our knowledge the first to analyze gene differential expression in Moroccan women. Focusing on the mRNA expression machinery may help to better understand gene interactions and explore new possibilities for BC targeted therapy.

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Published

02-02-2019

Issue

Vol 8, Supplement 2 (2019)

Section

Life Sciences (Medical, Health, Agriculture, Biology, Genetics)