Improving productivity is a vital objective that continues to generate an increasing interest in both public policies and growth prospects at the firm level. High productivity has strong implications for economic growth and welfare. This paper investigates the determinants of productivity in Senegalese manufacturing industries. Using the World Bank Enterprise survey data, our results show that wage and Manager’s experience are, as it stands, two key determinants positively affecting firms’ productivity. Playing on wage and experience in decision-making position will help to increase manufacturing productivity.