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In this work the objective is to determine the effect of mobile money on the self-employment of women in Africa. The pursuit of this objective required data, between 2010 and 2018, from the World Bank (2019) and the Financial Access Survey (2019). Thanks to the use of Panel Corrected Standard Error and the least squares possible, it appears that an increase in mobile money transactions is favorable to the self-employment of women in Africa. It also appears that the regulation of the private sector tends to discourage women in Africa to undertake and the refore to self-employ. These results suggest that mobile money should be encouraged among women in these countries. And that it is important to create a favorable business climate, which requires optimal regulation of the private sector.