Prevalence of Enterobacteriaceae producing carbapenemase (OXA-48) responsible for urinary tract infections in Casablanca.
DOI:
https://doi.org/10.34874/PRSM.mjph-vol3iss2.28294Keywords:
Enterobacteriaceae, Urinary tract infection, Antibiotic resistance, carbapenemases.Abstract
In recent years, we have witnessed the appearance of strains increasingly resistant to antibiotics. The large-scale spread of this resistance in the community today suggests that it will become a major public health problem shortly. Among the resistant strains are Enterobacteriaceae, which are responsible for numerous infections, particularly urinary tract infections. The present study focused on the phenotypic and genotypic characterization of uropathogenic enterobacteria isolated from the community environment. Our study included a total of 78 strains collected from UTIs during the year 2019. The confirmation of the species was performed by the Biomérieux VITEK system. The study of their antibiotic resistance was carried out by the method of diffusion on agar Mueller Hinton according to the recommendations of SFM-EUCAST 2019.The search for resistance genes bla(NDM, KPC, OXA-48) was performed by PCR. The results obtained showed that out of 78 samples of urinary enterobacteria, E.coli species dominated by a percentage of 58%, followed by K.pneumonia at 33%, and E.cloacae 8%. The study of antibiotic resistance profile showed high resistance to penicillins 91% followed by cephalosporins 58%. Carbapenems have a low activity on the studied strains with resistance percentages of 41% and 33% for imipenem and ertapenem respectively. The carbapenems resistance study allowed the detection of the blaOXA-48gene in three strains among the studied strains.References
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