Cytogenetic analysis and SRY gene detection in four moroccan brothers with Disorder of sex development

Zouhair ELKARHAT, Hicham CHAROUTE, Yassine NAASSE, Abdelhamid BARAKAT, Hassan ROUBA

Abstract


The objective of this study is to determine the genetic cause of the disorder of sex development on Moroccan family. Indeed, the genomics and human genetics laboratory at the Pasteur Institute of Morocco recruited four brothers with ambiguous genitalia. Cytogenetic analysis of the first brother revealed the presence of a chimeric karyotype 46, XX/46, XY with the presence of the SRY gene. The other three brothers present a normal female karyotype 46, XX with the presence of the SRY gene.



Keywords


Disorder of sex development; Ovotesticular DSD; Ambiguous genitalia; SRY gene

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References


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DOI: https://doi.org/10.80481/revuetest26922

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