SARS-CoV-2 virus genome structure and evolution

Chaimae SAMTAL, Nihal HABIB, Abdellah IDRISSI AZAMI, Sofia SEHLI, Bouchra CHAOUNI, Mohamed BEKKALI, Hicham BEKKARI, Salsabil HAMDI, Lahcen WAKRIM, Najib Al IDRISSI, Hassan GHAZAL


Late December 2019, a new virus outbreak was detected in Wuhan, Hubei province China and later spread all over the world.The virus is a new strain of the β-Coronavirus (SARS-CoV-2) with a single strand positive sense RNA, and a genome size of 29,890 kb that codes for 9744 amino acids. Not many mutations are depicted in the SARS-CoV-2 genome, However, most of them are detected in the ORF8 regionand the spike. The latter exhibits higher affinity with the Human ACE2 receptor than the SARS-CoV.Alignment of SARS-CoV-2 genome with other Corona viruses shows a high similarity to the Bat-CoV,but this latter was not enough to conclude that the Bat is the origin of the Human SARS-CoV-2. This review aimed to provide an overview of the viral genome structure and its origin.


SARS-Cov-2; coronavirus phylogeny; alignment; ACE2

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