The phase diagrams of the ferromagnetic two-dimensional mixed spin-1 and spin-1/2 Ising model with four-spin interaction J4 and next-nearest couplings J’ are investigated by the use of the finite cluster approximation based on single-site cluster theory. The state equations are derived for the two-dimensional square lattice. The phase diagram is qualitatively and quantitatively different from that obtained when the interaction J’ is ignored. In fact, the system exhibits a variety of interesting features resulting from the introduction of the next-nearest neighbor interaction (NNN). It undergoes two kinds of behavior according to the negative and the positive value of J’. In particular, for J4/J2=-4, the system keeps the coexistence of the two ground state up to J’-dependent finite temperature.