SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF 3-AZOLYL-2- METHYL-PYRIDO[1,2-a]PYRIMIDIN-4-ONE DERIVATIVES

Authors

  • Sanae Lahmid
  • Youssef Kandri Rodi
  • El Mokhtar Essassi

Abstract

The condensation of the binucleophilic reagents hydrazine hydrate and
hydroxylamine hydrochloride on 3-acetoacetyl-2-methyl-pyrido[1,2-a]pyrimidin-4-one 3
acting as a heterocyclic β-diketone affords 3-azolyl-2-methyl-pyrido[1,2-a]pyrimidine
derivatives 4 and 7. The alkylation of 3-pyrazolyl-pyrido[1,2-a]pyrimidin-4-one with allyl
bromide under phase transfer catalysis gives exclusively 3-[(1-prop-2-en-1-yl) 5-methypyrazol-3-yl]-2-methyl-pyrido[1,2-a] pyrimidin-4-one.
A plausible mechanism for the formation of the obtained compounds 4 and 7 have been
proposed and discussed.

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Published

05-03-2024

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Section

Articles