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Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats


 
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1. Title Title of document Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats
 
2. Creator Author's name, affiliation, country Elwaleed E. Ibrahim; Department of Pharmacology & Toxicology, National Centre for Research, MAPRI, Khartoum, Sudan.
 
2. Creator Author's name, affiliation, country Abd-Elwahab H. Mohamed; Department of Pharmacology & Toxicology, National Centre for Research, MAPRI, Khartoum, Sudan.
 
2. Creator Author's name, affiliation, country Assad Khalid; Department of Medical Biochemistry, National Centre for Research, MAPRI, Khartoum, Sudan.
 
2. Creator Author's name, affiliation, country Ashraf N. Abdalla; College of Pharmacy, UmmAlqura University, Makkah, KSA.
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Balanites aegyptiaca (L.) Delile; Hepatoprotective
 
4. Description Abstract

Methanolic extract of Balanites aegyptiaca (L.) Delile (leaves), was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatic damage in Wistar rats; by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin. Histological studies were also carried out to support our hypothesis. Administration of the extract (200 and 400 mg/kg) orally markedly prevented CCl4-induced elevation of serum GPT, GOT, ALP and total bilirubin levels. A comparative histopathological study of liver in treated groups exhibited similarity to normal tissue architecture, compared to CCl4-treated group.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 21-03-2016
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/AJMAP/article/view/4860
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48347/IMIST.PRSM/ajmap-v2i1.4860
 
11. Source Title; vol., no. (year) Arabian Journal of Medicinal and Aromatic Plants; Vol 2, No 1 (2016)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c)