Comparative study of in-vitro antioxidant, anti-acetylcholinesterase, anti-xanthine oxidase, anti-5-lipoxygenase, anti-α-amylase and cytotoxic activity of Acacia species (Mimosaceae)
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| 1. | Title | Title of document | Comparative study of in-vitro antioxidant, anti-acetylcholinesterase, anti-xanthine oxidase, anti-5-lipoxygenase, anti-α-amylase and cytotoxic activity of Acacia species (Mimosaceae) |
| 2. | Creator | Author's name, affiliation, country | Hichem BEN JANNET; Faculté des Sciences de Monastir, Université de Monastir; Tunisia |
| 2. | Creator | Author's name, affiliation, country | Amira Jelassi; Faculté des Sciences de Monastir, Université de Monastir |
| 2. | Creator | Author's name, affiliation, country | Mayssa Ben Mustapha; Faculté des Sciences de Monastir, Université de Monastir |
| 2. | Creator | Author's name, affiliation, country | Mansour Znati; Faculté des Sciences de Monastir, Université de Monastir |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Acacia species; extracts; xanthine oxidase; 5-lipoxygenase; α-amylase; antioxidant; cytotoxic |
| 4. | Description | Abstract | The present study aimed the investigation of the acetylcholinesterase, xanthine oxidase (XOD), 5-lipoxygenase, α-amylase, antioxidant and cytotoxic activities of various organic extracts from seeds and pods of two Tunisian species of Acacia, A. cyclops and A. mollissima (Mimosaceae). At concentrations of 50 µg/mL, EtOAc extract of seeds from A. mollissima was able to strongly inhibit xanthine oxidase (XOD) with 98.40%. Moreover, EtOAc and n-BuOH extracts from pods of A. mollissima showed the highest inhibitor activity against 5-lipoxygenase with percentages of 79.60 and 64.86% inhibition, respectively. However, most of the tested extracts were not good acetylcholinesterase inhibitors. n-BuOH extracts of pods displayed the highest antioxidant activity (IC50= 36.03 to 45.90 µg/mL) for the DPPH assay and confirmed with the ABTS test. The eight extracts of Acacia species were tested for their cytotoxic activity in vitro using MCF-7, HCT-116, IGROV-1 and OVCAR-3 cell lines. The most active extracts were those of A. cyclops against IGROV-1 ranging from 12.9 to 16.1 µg/mL. |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 20-05-2023 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://revues.imist.ma/index.php/AJMAP/article/view/34173 |
| 10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.48347/IMIST.PRSM/ajmap-v9i1.34173 |
| 11. | Source | Title; vol., no. (year) | Arabian Journal of Medicinal and Aromatic Plants; Vol 9, No 1 (2023) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2023 Arabian Journal of Medicinal and Aromatic Plants This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |