Indexing metadata

Essential oil of Seseli tortuosum L. from Portugal: safety and anti-inflammatory potential evaluation


 
Dublin Core PKP Metadata Items Metadata for this Document
 
1. Title Title of document Essential oil of Seseli tortuosum L. from Portugal: safety and anti-inflammatory potential evaluation
 
2. Creator Author's name, affiliation, country C. Cabral; Centro de Estudos Interdisciplinares do Século XX da Universidade de Coimbra - CEIS20, Rua Filipe Simões nº 33, 3000-186 Coimbra, Portugal Centro de Neurociências e Biologia Celular e Faculdade de Farmácia, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Universidade de Coimbra, 3000-295 Coimbra, Portugal
 
2. Creator Author's name, affiliation, country M.F. Lemos; MARE – Marine and Environmental Sciences Centre, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, Portugal
 
2. Creator Author's name, affiliation, country C. Cavaleiro; Centro de Neurociências e Biologia Celular e Faculdade de Farmácia, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Universidade de Coimbra, 3000-295 Coimbra, Portugal
 
2. Creator Author's name, affiliation, country M.T. Cruz; Centro de Neurociências e Biologia Celular e Faculdade de Farmácia, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Universidade de Coimbra, 3000-295 Coimbra, Portugal
 
2. Creator Author's name, affiliation, country L. Salgueiro; Centro de Neurociências e Biologia Celular e Faculdade de Farmácia, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Universidade de Coimbra, 3000-295 Coimbra, Portugal
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Seseli tortuosum, essential oil, cytotoxicity, anti-inflammatory activity, nitric oxide
 
4. Description Abstract

Several Seseli L. (Apiaceae) species are used in folk medicine for several healing effects, namely herbal remedy for human inflammation, swelling, rheumatism, pain and common cold. In Portugal, there are two taxa usually used in traditional medicine: Seseli tortuosum L. and Seseli montanum subsp. peixotoanum (Samp.). The aim of the present research was to evaluate the anti-inflammatory activity of S. tortuosum and to assess their safety profile in several mammalian cell types at concentrations presenting strong bioactivity. This oil is characterized by high percentage of α-pinene (21.1%), β-pinene (22.6%) and cis-β-ocimene (11.8). The anti-inflammatory potential was investigated in lipopolysaccharide (LPS)-triggered nitric oxide (NO) production by macrophages and microglia concomitantly treated with S. tortuosum essential oil. Our results demonstrated a significant decrease of LPS-induced NO production at concentrations up to 0.16 μL/mL, without affecting cell viability. Our findings confirm the safety of S. tortuosum oil in doses with anti-inflammatory activity. These results support further studies envisaging the use of S. tortuosum oil in pharmaceutical formulations for inhalation, topical application or oral administration.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 13-08-2015
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://revues.imist.ma/index.php/AJMAP/article/view/3256
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.48347/IMIST.PRSM/ajmap-v1i1.3256
 
11. Source Title; vol., no. (year) Arabian Journal of Medicinal and Aromatic Plants; Vol 1, No 1 (2015)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c)