Antithrombotic activity of flavonoid fractions of Juglans regia root bark through inhibiting platelet aggregation and plasmatic coagulation
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| 1. | Title | Title of document | Antithrombotic activity of flavonoid fractions of Juglans regia root bark through inhibiting platelet aggregation and plasmatic coagulation |
| 2. | Creator | Author's name, affiliation, country | Asmae AMIROU; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Abdelkhaleq LEGSSYER; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Abderrahim ZIYYAT; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mohammed AZIZ; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mohamed BNOUHAM; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mohammed BERRABAH; Laboratory of Mineral Solid and Analytical Chemistry, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mostafa MARKAOUI; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mohammed BENSAID; Laboratory Bensaid of Pathological Cytology and Anatomy, 100, Allal Ben Abdellah Street, Apartment number 9, Oujda; Morocco |
| 2. | Creator | Author's name, affiliation, country | Younes ZAID; Research Center of Abulcasis University of Health Sciences, Rabat, Morocco AND Department of Biology, Faculty of Sciences, Mohammed V University, Rabat; Morocco |
| 2. | Creator | Author's name, affiliation, country | Hassane MEKHFI; Laboratory of Bio-resources, Biotechnologies, Ethnopharmacology, and Health, Department of biology, Faculty of Sciences University Mohammed First Oujda; Morocco |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Acute thromboembolism; Coagulation; Flavonoids; Juglans regia; Platelet aggregation. |
| 4. | Description | Abstract | Thrombus formation in cardiovascular diseases is one of the important mechanisms responsible for death and disability. Plants have long been used as traditional remedies for the treatment of many diseases. In this study, we investigated the antithrombotic, antiaggregant, and anticoagulant activities of flavonoids isolated from Juglans regia root bark. The antithrombotic activity was evaluated on collagen plus epinephrine induced acute pulmonary thromboembolism model of mice and murine platelet aggregation was induced by different agonists. Clotting parameters including activated partial thromboplastin time, prothrombin time, and thrombin time in the platelet-poor plasma were determined in vitro by using a coagulometer in the presence and absence of flavonoid fractions. Flavonoids extracted from Juglans regia exhibited an antithrombotic activity (80% of protection) by preventing the paralysis or death induced by an intravenous injection of collagen and epinephrine. In addition, these compounds significantly inhibited platelet aggregation and prolonged the plasmatic coagulation time. Flavonoids isolated from Juglans regia exert a potent antithrombotic effect via antiaggregant and anticoagulant actions. Juglans regia could be a precious source of antithrombotic compounds. |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | All authors contributed to this study; This work was supported by grants from the Ministère de l’Éducation Nationale, de l’Enseignement Supérieur, de la Recherche Scientifique and the CNRST (Morocco): Project PPR2-P9 (type A). |
| 7. | Date | (YYYY-MM-DD) | 12-12-2022 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://revues.imist.ma/index.php/AJMAP/article/view/29580 |
| 10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.48347/IMIST.PRSM/ajmap-v8i3.29580 |
| 11. | Source | Title; vol., no. (year) | Arabian Journal of Medicinal and Aromatic Plants; Vol 8, No 3 (2022) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2022 Arabian Journal of Medicinal and Aromatic Plants This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |