Evaluation of toxicity, nephroprotective and hepatoprotective activities of Argan oil on CCl4-induced nephrotoxicity and hepatotoxicity in Wistar rats
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| 1. | Title | Title of document | Evaluation of toxicity, nephroprotective and hepatoprotective activities of Argan oil on CCl4-induced nephrotoxicity and hepatotoxicity in Wistar rats |
| 2. | Creator | Author's name, affiliation, country | Bnouham Mohamed; University Mohamed First, Boulevard Mohamed VI; Oujda, Morocco; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mamri Samira; University Mohamed First, Boulevard Mohamed VI; Oujda, Morocc; Morocco |
| 2. | Creator | Author's name, affiliation, country | Marghich Mohamed; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 2. | Creator | Author's name, affiliation, country | Bouziane Omar; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 2. | Creator | Author's name, affiliation, country | Bouhrim Mohamed; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 2. | Creator | Author's name, affiliation, country | Saalaoui Ennouamane; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 2. | Creator | Author's name, affiliation, country | Choukri Mohammed; Central Laboratory Service - CHU, Mohammed VI, Oujda, Morocco; Morocco |
| 2. | Creator | Author's name, affiliation, country | Mekhfi Hassane; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 2. | Creator | Author's name, affiliation, country | Legssyer Abdelkhaleq; University Mohamed First, Boulevard Mohamed VI; Oujda, Morocc; Morocco |
| 2. | Creator | Author's name, affiliation, country | Ziyyat Abderrahim; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 2. | Creator | Author's name, affiliation, country | Bnouham1 Mohamed; University Mohamed First, Boulevard Mohamed VI; Oujda,; Morocco |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Argania spinosa seed oil, CCl4, hepatoprotective, nephroprotective, roasting process. |
| 4. | Description | Abstract | In traditional therapy, Argania spinosa L. seeds oil used as a nephroprotective and hepatoprotective agent. The present work aims to investigate the acute toxicity of unroasted Argan oil, and studied the nephroprotective and the hepatoprotective activity of both oils Roasted (Roil) and unroasted Argan oil (UnRoil) on CCl4-induced liver and kidney damages in Wistar rats. Animals were divided into five equal groups; Control and CCl4 groups are received only distilled water (10 mL/Kg/day). Control positive group received 50 mg/Kg/day of Silymarin. Roil and UnRoil groups treated with 2 mL/Kg/day of Roil and UnRoil. One week after each pretreatment, the rats are injected intraperitoneally with 1 mL/kg/week of CCl4. The treatment has lasted for 15 days. The body weight, urinary volume, water, and food intake were measured at the end of the treatment. Then, the animals are sacrificed; the blood and the liver samples were collected for determining the liver weight ratio and biochemical parameters. UnRoil did not show any sign of toxicity up to 5 mL/Kg. In Roil and UnRoil groups the water intake, ALT, AST, total and direct bilirubin, triglycerides, LDL, plasmatic creatinine, urea, uric acid, and MDA levels are reduced significantly as compared with the CCl4 group. However, body weight,liver weight ratio, food intake, urine urea, urinary creatinine, hepatic glycogen, and GSH levels showed a significant increase compared to the CCl4 group. Roil and UnRoil showed important nephroprotective and hepatoprotective effects against CCl4. Although, the roasting process does not influence the ability of Argan seed oils towards these activities. Keywords: |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | This work was supported by grants from the CNRST of Morocco (Project PPR2). |
| 7. | Date | (YYYY-MM-DD) | 04-10-2021 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://revues.imist.ma/index.php/AJMAP/article/view/28408 |
| 10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.48347/IMIST.PRSM/ajmap-v7i3.28408 |
| 11. | Source | Title; vol., no. (year) | Arabian Journal of Medicinal and Aromatic Plants; Vol 7, No 3 (2021) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2021 Arabian Journal of Medicinal and Aromatic Plants This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |