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This study emphasizes screening of DPPH, secondary metabolites and antimicrobial activity of Blastonia garciniian annual wine with a slender stem, climbing using tendrils, leaves are ovate and flowers are unisexual.  The leaves were collected, shade dried and powdered. The powdered sample was extracted by using soxhlet apparatus with petroleum ether and ethanol. The antioxidant activity of the plant extracts was measured using spectrophotometry by their ability to scavenge free radicals such as DPPH (2,2-diphenyl-1-picrylhydrazyl), hydrogen peroxide and also quantification of total flavonoids, total phenol content and antimicrobial activity of plant extracts. The significant result observed in when compared Petroleum ether and Ethanol extract, the DPPH and H₂O ₂ activities and the total phenol and total flavonoïd content and Antibacterial and antifungal activity were shown significant activity in ethanolic extract of B. garcinii.