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Khaya senegalensis and Tamarindus indica are widely used medicinal plant in many parts of Africa to manage infectious diseases. The barks of these plants were screened for their phytochemicals and their bioactivityactivity against some clinical pathogenic microorganisms. Results of the phytochemical screening showed that tha aqueous, methanolic and ethanolic extracts of the barks of the plants contain saponins, tannins, basalms, glycosides, steriods, terpenoidsand flavonoids. The antimicrobial susceptibility test showed that bark extracts of Khaya senegalensis and Tamarindus indica had varying inhibition strength on the test organisms. The aqueous, ethanolic and methanolic extracts of Khaya senegalensis had the highest zone of inhibition on three of the isolates which were; Pseudomonas 27853, Klebsiella pneumonia and Escherichia coli (Carbapenem-resistant strain). While the aqueous, ethanolic and methanolic extracts ofTamarindus indica barksinhibited Methicillin-resistant Staphylococcus aureus 4330, Klebsiella pneumonia and Echerichia coli (non-carbapenem strain). The minimum inhibitory concentration of the bark extracts ranged from 400mg/ml to 25mg/ml. There was no minimum bactericidal concentration observed from the extracts. Antibiotics susceptibility test using standard antibiotics indicated multidrug resistance by the test organisms which Ceftriaxone (CRO) 30µg and Cefepime (FEP) 30µg elicited inhibitory activity against Carbapenem-resistant pseudomonas species, Pseudomonas aerigunosa ATCC 27853,and Echerichia coli (non- carbapenem strain) respectively. The result of this study, therefore suggest the possibility of using Khaya senegalensis and Tamarindus indica extracts as antimicrobial agents, which can be a great asset to drug development for purpose of health care delivery in Nigeria.