Effect of Co-administration of Single and Multiple Doses of Piperine on the Pharmacokinetics of Tamoxifen in Rats

Abstract

The aim of this study was to investigate the effect of single and multiple oral administration of piperine on the pharmacokinetics of tamoxifen in rats.  Tamoxifen was administered orally alone at 10 mg/kg or with singles (10, 25 and 50 mg/kg) or multiple (10 mg/kg) oral doses of piperine.  In the present study, compared with the control group (tamoxifen alone) and piperine single and multiple dose administration showed significant increase in AUC_0-∞ and t_1/2. The relative bioavailability of tamoxifen in the piperine treated groups was 2.15-2.39 times higher compared to control group. The present study revealed that piperine significantly improved bioavailability of tamoxifen and the influence of piperine on the pharmacokinetics of tamoxifen may be attributed to the inhibition of metabolism of tamoxifen.