Toxicity Assessment of Sarcocephalus latifolius Root Extract

Authors

  • Atchadé Pascal Tchogou Laboratory of Pharmacology and Improved Traditional Medicines, Faculty of Science and Technology, University of Abomey Calavi

DOI:

https://doi.org/10.48347/IMIST.PRSM/ajmap-v9i3.49260

Abstract

This research endeavors to investigate the potential toxic effects of an aqueous extract obtained from Sarcocephalus latifolius roots, administered via gavage, on the renal and hepatic functions of Wistar rats. The extraction process yielded 10.80% of the target compound. The determination of the lethal dose 50 (LD50) revealed a value of 3750 mg/kg body weight (BW), indicating slight toxicity when administered at doses exceeding 2500 mg/kg BW, within the parameters of this study. To assess liver and kidney toxicity, the rats received daily gavage doses of 0 mg/kg, 100 mg/kg, 200 mg/kg, and 300 mg/kg of body weight. Biochemical parameter measurements, including ASAT, ALAT, alkaline phosphatase, urea, creatinine, and uric acid, conducted throughout the study, demonstrated that there was no significant increase in these parameters at doses below 100 mg/kg BW. However, a noteworthy increase was observed at doses exceeding 100 mg/kg BW. These findings tentatively suggest potential organ damage, which was not corroborated by the histological examination of the excised liver and kidney tissues. This histological analysis indicates an absence of hepatic cytolysis and the preservation of renal function despite the observed biochemical changes.

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Published

02-06-2024

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Section

Research Articles