Aqueous extract of Cucumis sativus fruit attenuates Rheumatoid Arthritis Associated disorders on animal model of rheumatoid arthritis induced by formaldehyde

Martin Fonkoua, Grace Fopa Lambou, Guy Takuissu Nguemto, Dany Ngoumen Ngassa, Janvier Youovop, Catherine Abeng Edoa, Judith Laure Ngondi, Julius Oben Enyong


Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease with presently unknown cure. However, its management involves the reduction of pain, and immunological and biochemicals disorders. Natural plants have been proven to be safe and less cost-effective treatment for arthritis management. The study aimed at evaluating the effects of the aqueous extracts of Cucumis sativus fruits on inflammation and cartilage erosion in an animal model of rheumatoid arthritis. RA was induced in female wistar rats by injecting formaldehyde (2% v/v in saline solution) into the sub‐plantar region of their left hind paw. Animals were then treated by daily gavage (400 mg/kg bw) of C. sativus aqueous extract or glucosamine/chondroitin (a dietary complement) for 14 days. The weight of the animals and the diameter of the edemas were recorded every 3 days. The rats were sacrificed, and the blood collected for the evaluation of hematological and biochemical parameters (C-reactive protein and plasma Ca2+, Mg2+ levels). The aqueous extract of C. sativus exhibited an enthralling suppression in edema of treated animals at the end of the study with 64.91% of protection like glucosamine/chondroitin. In addition, it increased the levels of lymphocytes and polymorphonuclear cells and significantly reduced C-reactive protein, calcium and magnesium levels when compared to the disease control group. Thus, the current study showed that the aqueous extract of C. sativus possesses anti-arthritic activities making it therefore a promising agent for the management of disorders associated to RA.


Antiarthritic Activity, Cucumis sativus fruit,formaldehyde,inflammation.

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ISSN: 2458-5920