Aqueous extract of Cucumis sativus fruit attenuates Rheumatoid Arthritis Associated disorders on animal model of rheumatoid arthritis induced by formaldehyde

Authors

  • Martin Fonkoua Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Grace Fopa Lambou Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Guy Takuissu Nguemto Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Dany Ngoumen Ngassa Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Janvier Youovop Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Catherine Abeng Edoa Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Judith Laure Ngondi Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon
  • Julius Oben Enyong Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon

DOI:

https://doi.org/10.48347/IMIST.PRSM/ajmap-v8i3.33408

Keywords:

Antiarthritic Activity, Cucumis sativus fruit, formaldehyde, inflammation.

Abstract

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease with presently unknown cure. However, its management involves the reduction of pain, and immunological and biochemicals disorders. Natural plants have been proven to be safe and less cost-effective treatment for arthritis management. The study aimed at evaluating the effects of the aqueous extracts of Cucumis sativus fruits on inflammation and cartilage erosion in an animal model of rheumatoid arthritis. RA was induced in female wistar rats by injecting formaldehyde (2% v/v in saline solution) into the sub‐plantar region of their left hind paw. Animals were then treated by daily gavage (400 mg/kg bw) of C. sativus aqueous extract or glucosamine/chondroitin (a dietary complement) for 14 days. The weight of the animals and the diameter of the edemas were recorded every 3 days. The rats were sacrificed, and the blood collected for the evaluation of hematological and biochemical parameters (C-reactive protein and plasma Ca2+, Mg2+ levels). The aqueous extract of C. sativus exhibited an enthralling suppression in edema of treated animals at the end of the study with 64.91% of protection like glucosamine/chondroitin. In addition, it increased the levels of lymphocytes and polymorphonuclear cells and significantly reduced C-reactive protein, calcium and magnesium levels when compared to the disease control group. Thus, the current study showed that the aqueous extract of C. sativus possesses anti-arthritic activities making it therefore a promising agent for the management of disorders associated to RA.

Author Biography

Guy Takuissu Nguemto, Laboratory of Nutrition and nutritional Biochemistry,Departement of Biochemistry,The University of Yaoundé 1,Cameroon

Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O Box: 13033, Yaounde-Cameroon

 

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Published

12-12-2022

Issue

Vol. 8 No. 3 (2022)

Section

Research Articles

License

The Corresponding Author transfers and assigns to the Arabian Journal of Medicinal and Aromatic Plants  (AJMAP) , during the full term of copyright and any extensions or renewals of that term, all copyright in and to the Work,  including but not limited to the right to publish, republish, transmit, sell, distribute and otherwise use the Work in electronic and print editions of the Journal and in derivative  works throughout the world, in all languages and in all media now known or later developed, and to license or permit others to do so.