Primary Fourth Ventricular B-cell Lymphoma: Case Report and Literature Review

Brahim Eljebbouri, Miloudi Gazzaz, Adil Belhachmi, Mohammed Mrabti, Jawad Laaguili, Brahim ElMostarchid

Résumé


-BACKGROUND: Primary central nervous lymphoma (PCNSL) is a rare variant of extranodal non-Hodgkin's lymphoma with a especially poor
prognosis. The diagnosis is usually encountered in immunodeficient
patients but is also encountered, albeit uncommonly, in the
immunocompetent. The finding of PCNSL in the fourth ventricle is very
unusual.
-CASE DESCRIPTION: A 23-year-old woman had a 7 months history of
intermittent vertigo, nausea, vomiting, and progressively unsteady gait.
MRI of the brain revealed a 4.5 cm enhancing tumor in the fourth
ventricle. Metastasis or high-grade glioma was suspected. The
neuropathological findings -after surgery- were compatible with a diffuse
large B-cell lymphoma. A slit lamp examination, bone marrow biopsy, and
imaging studies for extracranial lesions were unremarkable.
-CONCLUSIONS: We suggest that PCNSL be listed in the differential
diagnosis of fourth ventricle tumors with well-circumscribed margins and
homogenous contrast enhancement.


Mots-clés


Central nervous system; Diffuse large-cell lymphoma; Fourth ventricle tumor; Immunocompetence

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