Clinicopathologic Features and Molecular Subtypes of BreastT Cancer in 390 Patientsin Fez-Meknes Region- Morocco

Sanae Chahbouni, Afaf Amarti, Nawal Hammas, Leila Chbani, Hind Elfatemi

Abstract


Background: Breast cancer is the most common malignant tumor in women; it is different from other malignant tumors in that it appears to be heterogeneous in outcomes. Although individual molecular markers were introduced in the field of breast cancer management many years ago, the concept of molecular classification was raised after the introduction of global gene expression profiling and the identification of multigene classifiers. 

Methods. This is a prospective study conducted in the department of Pathology in Hassan IId University , Fez, Morocco. A descriptive analysis of clinical, histological and immunohistochemical characteristics of four molecular subtypes of breast cancer was performed (Luminal A, Luminal B, HER2 over expression and triple negative phenotypes).

Results. In our survey, 390 cases of breast mammary carcinoma were observed; the most common subtype was luminal B. The luminal A subtype is significantly associated with the presence of ductal carcinoma in situ. 64% of triple negative phenotype tumors were Grade III SBR, and 57% of HER 2 phenotype tumors were Grade II SBR with a significant difference. 90% of the infiltrating lobular carcinomas are of luminal phenotype.

Conclusions. Our study shows that the luminal subtype B is the most common molecular subtype, which is a peculiarity of our series. There was also a significant difference between the molecular sub-types and the SBR grade, which is in line with previous observations.


Keywords


Breast, Cancer, Molecular, Morocco, Subtypes.

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